منابع مشابه
Self-Renewal of Stem Cells
Asymmetric division is one of the most fundamental characteristics of adult stem cells , which ensures one daughter cell maintains stem cell status and the other daughter cell becomes committed to differentiation. New data emerged recently that allow us to conclude that asymmetric division has another important aspect: it enables self-maintenance of stem cells.
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The cancer stem cell (CSC) or cancer-initiating cancer (C-IC) model has garnered considerable attention over the past several years since Dick and colleagues published a seminal report showing that a hierarchy exists among leukemic cells. In more recent years, a similar hierarchical organization, at the apex of which exists the CSC, has been identified in a variety of solid tumors. Human CSCs a...
متن کاملHighlight: self-renewal signaling in stem cells.
A number of ground-breaking studies recently identified sets of nuclear factors that together have the unique ability to ‘reset’ an adult differentiated cell type and to ‘erase’ all previous fate decisions and the transcriptional programs that determine phenotype and function of a differentiated cell (Takahashi et al., 2007; Wernig et al., 2007; Yu et al., 2007). As a result, ‘reprogrammed’ cel...
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The inner lining of the gut is a simple epithelium that completely selfrenews every five days because of the high mechanical and chemical stress. At the basis of the epithelial homeostasis are intestinal stem cells that are located at the bottom of crypts. Progeny is generated on a daily basis to compensate for the loss of differentiated cells that cover the villi. Under normal conditions, acti...
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Glioblastoma (GBM) is the most aggressive and destructive form of brain cancer. Animal models that can unravel the mechanisms underlying its progression are needed to develop rational and effective molecular therapeutic approaches. In this study, we report the development of mouse models for spontaneous gliomas representing distinct progressive stages of disease that are governed by defined gen...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2004
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1207947